MedscapeLIVE Psychiatry September 2024

Candid Dish on New Treatments—FINAL ROUND!

Faculty of the 23rd Annual Psychopharmacology Update Opine

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Introduction

Welcome back, Psychiatry Newsletter Readers! As a part of our Candid Dish series, we sat down with a handful of key opinion leaders and asked them what their real thoughts are on potential up-and-coming novel treatments. This month in the final round, Part 3 of Candid Dish, they share thoughts on these treatments:

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• Xylazine—solution or problem?
• Glycine transport inhibitor for cognitive deficits in schizophrenia
• New illicit drug classes (eg, nitazenes) on the horizon
• Fentanyl’s role in decreasing effectiveness of medications, and making treatment options more challenging, for opioid use disorders (OUD).

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Last month’s issue featured Round 2, giving you the downlow from thought leaders on the following treatments:

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• Ketamine and ECT in treatment resistant depression
• Psilocybin/psychedelics for treatment resistant depression, mood disorders, anxiety, and PTSD
• Asenapine transdermal antipsychotic
• Bupropion or theta burst transcranial magnetic stimulation
• Esmethadone for major depression
• Dexmedetomidine—sublingual alpha 2 adrenergic agonist medication for agitation

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Read on in Candid Dish Final Round for candid takes on these! Huge thanks to these faculty for offering their true opinions on these treatment options.

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Thank you to this month’s thought leaders for their candid thoughts and perspectives! Please contact me at colleen@cmhadvisors.com with any comments. –Colleen Hutchinson

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Candid Dish on New Treatments—Final Round!

23rd Annual Psychopharmacology Update Faculty Opine

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Xylazine—solution or problem (ie, wounds and ulcerations associated with its use).

Dr. Salsitz: Definitely a problem.

Dr. Goldberg: Toxin.

Dr. Nasrallah: Shelf it: there are better ways for analgesia, sedation, or anesthesia.

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Glycine transport inhibitor for cognitive deficits in schizophrenia.

Dr. Nasrallah: This may finally be the breakthrough for the long-awaited treatment of cognitive impairments in schizophrenia.

Dr. Citrome: Great, if it works.

Dr. Goldberg: Good luck.

Dr. Meyer: Iclepertin is a GlyT1 inhibitor with some early phase positive data. Stay tuned.

Dr. Correll: Mechanism of action with great promise and need, but prior failures.

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New illicit drug classes (eg, nitazenes) on the horizon.

Dr. Goldberg: New plague.

Dr. Salsitz: Ready or not, here come the nitazenes.

Dr. Nasrallah: Beware more needless death among the youth, and work on an effective antidote!

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Fentanyl’s role in decreasing effectiveness of medications, and making treatment options more challenging, for opioid use disorders (OUD).

Dr. Salsitz: Fentanyl has thrown a monkey wrench into treatment of OUD.

Dr. Goldberg: Plague.

Dr. Nasrallah: Fentanyl in tiny amounts is pure evil, and those who smuggle it into our country to kill hundreds of thousands deserve the guillotine.

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23rd Annual Psychopharmacology Update
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