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MedscapeLIVE Psychiatry September 2024

Candid Dish on New Treatments—FINAL ROUND!

Faculty of the 23rd Annual Psychopharmacology Update Opine

Introduction

Welcome back, Psychiatry Newsletter Readers! As a part of our Candid Dish series, we sat down with a handful of key opinion leaders and asked them what their real thoughts are on potential up-and-coming novel treatments. This month in the final round, Part 3 of Candid Dish, they share thoughts on these treatments:

  • Xylazine—solution or problem?
  • Glycine transport inhibitor for cognitive deficits in schizophrenia
  • New illicit drug classes (eg, nitazenes) on the horizon
  • Fentanyl’s role in decreasing effectiveness of medications, and making treatment options more challenging, for opioid use disorders (OUD).

Last month’s issue featured Round 2, giving you the downlow from thought leaders on the following treatments:

  • Ketamine and ECT in treatment resistant depression
  • Psilocybin/psychedelics for treatment resistant depression, mood disorders, anxiety, and PTSD
  • Asenapine transdermal antipsychotic
  • Bupropion or theta burst transcranial magnetic stimulation
  • Esmethadone for major depression
  • Dexmedetomidine—sublingual alpha 2 adrenergic agonist medication for agitation

Read on in Candid Dish Final Round for candid takes on these! Huge thanks to these faculty for offering their true opinions on these treatment options.

Thank you to this month’s thought leaders for their candid thoughts and perspectives! Please contact me at colleen@cmhadvisors.com with any comments. –Colleen Hutchinson

Candid Dish on New Treatments—Final Round!

23rd Annual Psychopharmacology Update Faculty Opine

Xylazine—solution or problem (ie, wounds and ulcerations associated with its use).

Dr. Salsitz: Definitely a problem.

Dr. Goldberg: Toxin.

Dr. Nasrallah: Shelf it: there are better ways for analgesia, sedation, or anesthesia.

Glycine transport inhibitor for cognitive deficits in schizophrenia.

Dr. Nasrallah: This may finally be the breakthrough for the long-awaited treatment of cognitive impairments in schizophrenia.

Dr. Citrome: Great, if it works.

Dr. Goldberg: Good luck.

Dr. Meyer: Iclepertin is a GlyT1 inhibitor with some early phase positive data. Stay tuned.

Dr. Correll: Mechanism of action with great promise and need, but prior failures.

New illicit drug classes (eg, nitazenes) on the horizon.

Dr. Goldberg: New plague.

Dr. Salsitz: Ready or not, here come the nitazenes.

Dr. Nasrallah: Beware more needless death among the youth, and work on an effective antidote!

Fentanyl’s role in decreasing effectiveness of medications, and making treatment options more challenging, for opioid use disorders (OUD).

Dr. Salsitz: Fentanyl has thrown a monkey wrench into treatment of OUD.

Dr. Goldberg: Plague.

Dr. Nasrallah: Fentanyl in tiny amounts is pure evil, and those who smuggle it into our country to kill hundreds of thousands deserve the guillotine.

Still Need to Earn CME? Don’t Miss These Events!

23rd Annual Psychopharmacology Update
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